Coronary artery disease is the leading cause of death in the United States. The combination of noninvasive cardiovascular testing and invasive cardiac procedures accounts for a substantial portion of the yearly healthcare expenditure in the United States. Although the diagnosis of ischemically-driven chest pain may appear to be simple and straightforward, it often takes an astute clinician to confirm that clinically significant coronary artery blockage is the cause of a patient's chest pain. Cardiovascular research has provided convincing evidence that aggressive treatment of hypertension and hyperlipidemia--along with a management plan, based on the patient's combined risk factor profile, that includes blood glucose assessment, tobacco cessation, weight loss, healthy eating choices, and consistent aerobic exercise--must be provided to achieve optimal care for our patients. Over the ensuing decade, we will likely continue to see a shift away from routine percutaneous treatment of coronary lesions in favor of an aggressive assessment of a patient's cardiac risk profile followed by a treatment plan centered on active patient involvement including appropriate lifestyle changes and selective medications.