Oppositinines A and B: new vasorelaxant beta-carboline alkaloids from Neisosperma oppositifolia

Chem Pharm Bull (Tokyo). 2010 Aug;58(8):1085-7. doi: 10.1248/cpb.58.1085.

Abstract

A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 2D NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta / drug effects
  • Aorta / metabolism
  • Apocynaceae / chemistry*
  • Carbolines / chemistry
  • Carbolines / isolation & purification
  • Carbolines / pharmacology*
  • Male
  • Molecular Structure
  • Nitric Oxide / metabolism
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Stems / chemistry*
  • Plants, Medicinal / chemistry
  • Rats
  • Rats, Wistar
  • Stereoisomerism
  • Vasodilator Agents / chemistry
  • Vasodilator Agents / isolation & purification
  • Vasodilator Agents / pharmacology*

Substances

  • Carbolines
  • Plant Extracts
  • Vasodilator Agents
  • oppositinine A
  • oppositinine B
  • Nitric Oxide