Abstract
A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 2D NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aorta / drug effects
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Aorta / metabolism
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Apocynaceae / chemistry*
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Carbolines / chemistry
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Carbolines / isolation & purification
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Carbolines / pharmacology*
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Male
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Molecular Structure
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Nitric Oxide / metabolism
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plant Stems / chemistry*
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Plants, Medicinal / chemistry
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Rats
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Rats, Wistar
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Stereoisomerism
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Vasodilator Agents / chemistry
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Vasodilator Agents / isolation & purification
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Vasodilator Agents / pharmacology*
Substances
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Carbolines
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Plant Extracts
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Vasodilator Agents
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oppositinine A
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oppositinine B
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Nitric Oxide