Molecular Basis of pathogenicity in Helicobacter pylori clinical isolates

Ivy Bastos Ramis; Tesiê Leopoldo Fonseca; Ernani Pinho de Moraes; Márcia Silveira Fernandes; Raul Mendoza-Sassi; Obirajara Rodrigues; Carlos Renan Varela Juliano; Carlos James Scaini; Pedro Eduardo Almeida da Silva

doi:10.1128/JCM.00472-10

Molecular Basis of pathogenicity in Helicobacter pylori clinical isolates

J Clin Microbiol. 2010 Oct;48(10):3776-8. doi: 10.1128/JCM.00472-10. Epub 2010 Aug 4.

Authors

Ivy Bastos Ramis¹, Tesiê Leopoldo Fonseca, Ernani Pinho de Moraes, Márcia Silveira Fernandes, Raul Mendoza-Sassi, Obirajara Rodrigues, Carlos Renan Varela Juliano, Carlos James Scaini, Pedro Eduardo Almeida da Silva

Affiliation

¹ Laboratório de Biologia Molecular, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.

Abstract

This study identified pathogenicity genes in 40 Helicobacter pylori clinical isolates. The cagA, vacA, and iceA genes were detected in 65%, 97.5%, and 97.5% of the isolates, respectively. The cagA, iceA1, and vacAs1a/m1 genes were related to erosive gastritis, whereas the vacAs2/m2 and iceA2 genes were associated with enanthematous gastritis.

MeSH terms

Antigens, Bacterial / genetics
Bacterial Outer Membrane Proteins / genetics
Bacterial Proteins / genetics
DNA, Bacterial / genetics
Helicobacter Infections / microbiology*
Helicobacter pylori / genetics*
Helicobacter pylori / isolation & purification
Helicobacter pylori / pathogenicity*
Humans
Polymerase Chain Reaction
Virulence Factors / genetics*

Substances

Antigens, Bacterial
Bacterial Outer Membrane Proteins
Bacterial Proteins
DNA, Bacterial
VacA protein, Helicobacter pylori
Virulence Factors
cagA protein, Helicobacter pylori
ice nucleation protein