Kick-sTARting HIV-1 transcription elongation by 7SK snRNP deporTATion

Nat Struct Mol Biol. 2010 Aug;17(8):928-30. doi: 10.1038/nsmb0810-928.

Abstract

The HIV-1 Tat protein promotes viral transcription elongation by recruiting P-TEFb to RNA element TAR on the viral mRNA. Recent work from D'Orso and Frankel uncovers unexpected aspects of this process.

Publication types

  • Comment
  • News

MeSH terms

  • Gene Expression Regulation, Viral*
  • HIV Long Terminal Repeat / genetics*
  • HIV-1 / genetics*
  • Models, Genetic
  • Positive Transcriptional Elongation Factor B / metabolism
  • RNA Polymerase II / metabolism
  • Ribonucleoproteins, Small Nuclear / metabolism*
  • Transcription, Genetic*
  • Transcriptional Activation / genetics
  • tat Gene Products, Human Immunodeficiency Virus / genetics
  • tat Gene Products, Human Immunodeficiency Virus / metabolism*

Substances

  • Ribonucleoproteins, Small Nuclear
  • tat Gene Products, Human Immunodeficiency Virus
  • Positive Transcriptional Elongation Factor B
  • RNA Polymerase II