Abstract
The HIV-1 Tat protein promotes viral transcription elongation by recruiting P-TEFb to RNA element TAR on the viral mRNA. Recent work from D'Orso and Frankel uncovers unexpected aspects of this process.
MeSH terms
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Gene Expression Regulation, Viral*
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HIV Long Terminal Repeat / genetics*
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HIV-1 / genetics*
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Models, Genetic
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Positive Transcriptional Elongation Factor B / metabolism
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RNA Polymerase II / metabolism
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Ribonucleoproteins, Small Nuclear / metabolism*
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Transcription, Genetic*
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Transcriptional Activation / genetics
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tat Gene Products, Human Immunodeficiency Virus / genetics
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tat Gene Products, Human Immunodeficiency Virus / metabolism*
Substances
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Ribonucleoproteins, Small Nuclear
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tat Gene Products, Human Immunodeficiency Virus
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Positive Transcriptional Elongation Factor B
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RNA Polymerase II