Graft-induced dyskinesias in Parkinson's disease: what is it all about?

Cell Stem Cell. 2010 Aug 6;7(2):148-9. doi: 10.1016/j.stem.2010.07.003.

Abstract

The treatment of Parkinson's disease with grafts of fetal ventral mesencephalic tissue has shown some success, but can result in graft-induced dyskinesias (GIDs). Recently in Science Translational Medicine, Politis et al. (2010) demonstrate that GIDs may originate from serotoninergic neurons that are cografted in these transplants.

MeSH terms

  • Animals
  • Brain Tissue Transplantation / adverse effects*
  • Buspirone / therapeutic use
  • Dyskinesias / drug therapy
  • Dyskinesias / etiology*
  • Fetal Tissue Transplantation / adverse effects*
  • Humans
  • Neurons / metabolism
  • Parkinson Disease / complications*
  • Parkinson Disease / surgery*
  • Serotonin / metabolism
  • Stem Cell Transplantation

Substances

  • Serotonin
  • Buspirone