Anticonvulsant hypersensitivity syndrome treated with intravenous immunoglobulin

David C Dredge; Elizabeth C Parsons; Lindsay P Carter; Kevin J Staley

doi:10.1016/j.pediatrneurol.2010.03.010

Anticonvulsant hypersensitivity syndrome treated with intravenous immunoglobulin

Pediatr Neurol. 2010 Jul;43(1):65-9. doi: 10.1016/j.pediatrneurol.2010.03.010.

Authors

David C Dredge¹, Elizabeth C Parsons, Lindsay P Carter, Kevin J Staley

Affiliation

¹ Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. david.dredge@bhs.org

PMID: 20682208
DOI: 10.1016/j.pediatrneurol.2010.03.010

Abstract

Anticonvulsant hypersensitivity syndrome is a severe, potentially life-threatening, reaction to the aromatic anticonvulsant medications. Reported here is a case of anticonvulsant hypersensitivity syndrome secondary to phenobarbital in a 2-year-old boy; he responded to drug withdrawal, corticosteroids, and intravenous immunoglobulin. The literature regarding treatment of this syndrome is reviewed.

Publication types

Case Reports

MeSH terms

Child, Preschool
Drug Hypersensitivity / therapy*
Humans
Immunoglobulins, Intravenous / therapeutic use*
Male
Phenobarbital / adverse effects*
Treatment Outcome

Substances

Immunoglobulins, Intravenous
Phenobarbital