Abstract
The structure of the alcohol dehydrogenase ADH-'A' from Rhodococcus ruber reveals possible reasons for its remarkable tolerance to organic co-solvents and suggests new directions for structure-informed mutagenesis to produce enzymes of altered substrate specificity or improved selectivity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohol Dehydrogenase / chemistry*
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Alcohol Dehydrogenase / metabolism
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Alcohols / chemical synthesis
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Alcohols / chemistry
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Crystallography, X-Ray
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Ketones / chemistry
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Models, Molecular
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Protein Conformation
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Rhodococcus / enzymology*
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Solvents / chemistry
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Substrate Specificity
Substances
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Alcohols
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Ketones
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Solvents
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Alcohol Dehydrogenase