Hepatoma-derived growth factor promotes the resistance to anti-tumor effects of nordihydroguaiaretic acid in colorectal cancer cells

Eur J Pharmacol. 2010 Oct 25;645(1-3):55-62. doi: 10.1016/j.ejphar.2010.07.033. Epub 2010 Aug 1.

Abstract

Hepatoma-derived growth factor (HDGF) is correlated with aggressive tumor behaviors such as invasion and angiogenesis. Nevertheless, the potential involvement of HDGF in cell resistance to natural plant phenols-based chemotherapy is still unclear. This study demonstrated that over-expression of HDGF could confer the resistance of human colorectal cancer (CRC) cells to nordihydroguaiaretic acid (NDGA) toxicity. Enforced expression of HDGF could inhibit NDGA-induced apoptosis through the mitochondrial pathway in CRC cells, and attenuate the inhibitory effect of NDGA on tumor growth. Therefore, our results suggest that HDGF represents a potential molecule associated with chemotherapy resistance, which may have major implications in improving chemotherapy of colorectal cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / physiology
  • Animals
  • Antineoplastic Agents / pharmacology*
  • Apoptosis
  • Caspase 8 / metabolism
  • Caspase Inhibitors
  • Cell Line, Tumor
  • Colorectal Neoplasms
  • Cytochromes c / antagonists & inhibitors
  • Drug Resistance, Neoplasm
  • Humans
  • Intercellular Signaling Peptides and Proteins / biosynthesis*
  • Intercellular Signaling Peptides and Proteins / genetics
  • Male
  • Masoprocol / pharmacology*
  • Membrane Potential, Mitochondrial / drug effects
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Neoplasm Transplantation
  • Transplantation, Heterologous

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antineoplastic Agents
  • Caspase Inhibitors
  • Intercellular Signaling Peptides and Proteins
  • hepatoma-derived growth factor
  • Masoprocol
  • Cytochromes c
  • Caspase 8