Abstract
Hepatoma-derived growth factor (HDGF) is correlated with aggressive tumor behaviors such as invasion and angiogenesis. Nevertheless, the potential involvement of HDGF in cell resistance to natural plant phenols-based chemotherapy is still unclear. This study demonstrated that over-expression of HDGF could confer the resistance of human colorectal cancer (CRC) cells to nordihydroguaiaretic acid (NDGA) toxicity. Enforced expression of HDGF could inhibit NDGA-induced apoptosis through the mitochondrial pathway in CRC cells, and attenuate the inhibitory effect of NDGA on tumor growth. Therefore, our results suggest that HDGF represents a potential molecule associated with chemotherapy resistance, which may have major implications in improving chemotherapy of colorectal cancer.
Copyright 2010 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / physiology
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Animals
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Antineoplastic Agents / pharmacology*
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Apoptosis
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Caspase 8 / metabolism
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Caspase Inhibitors
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Cell Line, Tumor
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Colorectal Neoplasms
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Cytochromes c / antagonists & inhibitors
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Drug Resistance, Neoplasm
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Humans
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Intercellular Signaling Peptides and Proteins / biosynthesis*
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Intercellular Signaling Peptides and Proteins / genetics
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Male
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Masoprocol / pharmacology*
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Membrane Potential, Mitochondrial / drug effects
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Neoplasm Transplantation
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Transplantation, Heterologous
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Antineoplastic Agents
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Caspase Inhibitors
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Intercellular Signaling Peptides and Proteins
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hepatoma-derived growth factor
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Masoprocol
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Cytochromes c
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Caspase 8