We report what we believe to be the first demonstration of the second and third harmonics in tellurite microstructured fibers pumped by a 1557 nm femtosecond fiber laser. The intensities of the second and third harmonics are enhanced by increasing the nonlinear coefficient of the tellurite microstructured fiber. By using tellurite microstructured fiber with a core diameter of approximately 2.7 microm, supercontinuum light expanding from 470 nm to 2400 nm could be achieved. The effects of the fiber-core diameter on the flatness of the supercontinuum light are also investigated when pumped at 1557 nm.