A mild and facile one-pot synthesis of N-methyl-acyl-pyrroles

Hassan Valizadeh; Ashraf Fakhari

doi:10.3390/molecules15052972

A mild and facile one-pot synthesis of N-methyl-acyl-pyrroles

Molecules. 2010 Apr 27;15(5):2972-9. doi: 10.3390/molecules15052972.

Authors

Hassan Valizadeh¹, Ashraf Fakhari

Affiliation

¹ Department of Chemistry, Faculty of Sciences, Azarbaijan University of Tarbiat Moallem, Tabriz, Iran. h-valizadeh@azaruniv.edu

Abstract

N-Methyl-3-acylpyrroles were synthesized via a multicomponent reaction of dimethylacetylene dicarboxylate (DMAD), N-methylhydroxylamine and acylchlorides in the presence of KHCO(3). For comparison both conventional and microwave protocols were examined in this procedure. The reaction is clean and gives the products in good to excellent yields under conventional heating conditions at 40 degrees C in anhydrous dichloromethane.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dicarboxylic Acids / chemistry
Hydroxylamine / chemistry
Microwaves
Pyrroles / chemical synthesis*

Substances

Dicarboxylic Acids
Pyrroles
Hydroxylamine