Regioselective Suzuki-Miyaura reaction: application to the microwave-promoted synthesis of 4,7-diarylquinazolines

Youssef Kabri; Pierre Verhaeghe; Armand Gellis; Patrice Vanelle

doi:10.3390/molecules15052949

Regioselective Suzuki-Miyaura reaction: application to the microwave-promoted synthesis of 4,7-diarylquinazolines

Molecules. 2010 Apr 27;15(5):2949-61. doi: 10.3390/molecules15052949.

Authors

Youssef Kabri¹, Pierre Verhaeghe, Armand Gellis, Patrice Vanelle

Affiliation

¹ Laboratoire de Pharmacochimie Radicalaire, Faculté de Pharmacie, Universités d'Aix-Marseille I, II et III - UMR CNRS 6264, Marseille cedex 05, France. youssef.kabri@univmed.fr

Abstract

New diarylquinazolines displaying pharmaceutical potential were synthesized in high yields from 4,7-dichloro-2-(2-methylprop-1-enyl)-6-nitroquinazoline by using microwave-promoted regioselective Suzuki-Miyaura cross-coupling reactions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Microwaves*
Organic Chemistry Phenomena
Pharmaceutical Preparations / chemical synthesis
Quinazolines / chemical synthesis*

Substances

Pharmaceutical Preparations
Quinazolines