Thiazolo[3,2-a]benzimidazoles: synthetic strategies, chemical transformations and biological activities

Khalid A Al-Rashood; Hatem A Abdel-Aziz

doi:10.3390/molecules15063775

Thiazolo[3,2-a]benzimidazoles: synthetic strategies, chemical transformations and biological activities

Molecules. 2010 May 26;15(6):3775-815. doi: 10.3390/molecules15063775.

Authors

Khalid A Al-Rashood¹, Hatem A Abdel-Aziz

Affiliation

¹ Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Abstract

The present review covers the recent synthetic strategies and chemical transformations of thiazolo[3,2-a]benzimidazoles and it also presents the highlights of the biological activities of these compounds.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Benzimidazoles / chemical synthesis*
Benzimidazoles / chemistry*
Benzimidazoles / pharmacology
Humans
Molecular Structure
Neuroprotective Agents / chemical synthesis
Neuroprotective Agents / chemistry
Neuroprotective Agents / pharmacology
Receptors, Metabotropic Glutamate / antagonists & inhibitors
Thiazoles / chemistry
Thiazoles / pharmacology

Substances

6-amino-N-cyclohexyl-N,3-dimethylthiazolo(3,2-a)benzimidazole-2-carboxamide
Antineoplastic Agents
Benzimidazoles
Neuroprotective Agents
Receptors, Metabotropic Glutamate
Thiazoles