Identification of a novel class of membrane-bound [NiFe]-hydrogenases in Thermococcus onnurineus NA1 by in silico analysis

Appl Environ Microbiol. 2010 Sep;76(18):6286-9. doi: 10.1128/AEM.00123-10. Epub 2010 Jul 23.

Abstract

In silico analysis of group 4 [NiFe]-hydrogenases from a hyperthermophilic archaeon, Thermococcus onnurineus NA1, revealed a novel tripartite gene cluster consisting of dehydrogenase-hydrogenase-cation/proton antiporter subunits, which may be classified as the new subgroup 4b of [NiFe]-hydrogenases-based on sequence motifs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cluster Analysis
  • Gene Components
  • Hydrogenase / classification
  • Hydrogenase / genetics*
  • Molecular Sequence Data
  • Multigene Family / genetics*
  • Phylogeny*
  • Protein Subunits / genetics
  • Thermococcus / enzymology*

Substances

  • Protein Subunits
  • Hydrogenase