Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) infects fully differentiated cells of the monocyte/macrophage lineage. Recently, CD163 was shown to be a cellular receptor capable of mediating infection of otherwise PRRSV non-permissive cell lines. CD163 is a macrophage differentiation antigen belonging to the scavenger receptor cysteine-rich (SRCR) family of membrane proteins. We provide a brief review of current knowledge regarding CD163 in relation to PRRSV infection, and propose a structure-based prediction of amino acid sequences involved in PRRSV interaction.
Copyright © 2010 Elsevier B.V. All rights reserved.
MeSH terms
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Animals
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Antigens, CD / chemistry
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Antigens, CD / genetics
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Antigens, CD / physiology*
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Antigens, Differentiation, Myelomonocytic / chemistry
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Antigens, Differentiation, Myelomonocytic / genetics
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Antigens, Differentiation, Myelomonocytic / physiology*
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Cell Line
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Macrophages / virology
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Porcine respiratory and reproductive syndrome virus / physiology*
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Receptors, Cell Surface / chemistry
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Receptors, Cell Surface / genetics
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Receptors, Cell Surface / physiology*
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Receptors, Virus / chemistry
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Receptors, Virus / genetics
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Receptors, Virus / physiology*
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Virus Internalization*
Substances
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Antigens, CD
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Antigens, Differentiation, Myelomonocytic
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CD163 antigen
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Receptors, Cell Surface
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Receptors, Virus