High but not low frequency stimulation of both the globus pallidus and the entopeduncular nucleus reduces 'compulsive' lever-pressing in rats

Oded Klavir; Christine Winter; Daphna Joel

doi:10.1016/j.bbr.2010.07.018

High but not low frequency stimulation of both the globus pallidus and the entopeduncular nucleus reduces 'compulsive' lever-pressing in rats

Behav Brain Res. 2011 Jan 1;216(1):84-93. doi: 10.1016/j.bbr.2010.07.018. Epub 2010 Jul 21.

Authors

Oded Klavir¹, Christine Winter, Daphna Joel

Affiliation

¹ Department of Psychology, Tel Aviv University, Ramat-Aviv, Tel Aviv 69978, Israel.

PMID: 20654653
DOI: 10.1016/j.bbr.2010.07.018

Abstract

The anti-compulsive effects of high and low frequency stimulation (LFS, HFS) of the entopeduncular nucleus and globus pallidus (the rat's equivalent, respectively, of the primate's internal and external segments of the globus pallidus) were assessed in the signal attenuation rat model of obsessive-compulsive disorder (OCD). HFS, but not LFS, of the two nuclei exerted an anti-compulsive effect, suggesting that HFS of either segment of the globus pallidus may provide an additional therapeutic strategy for OCD.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Analysis of Variance
Animals
Behavior, Animal / physiology*
Compulsive Behavior / physiopathology*
Compulsive Behavior / therapy
Deep Brain Stimulation / methods*
Disease Models, Animal
Entopeduncular Nucleus / physiology*
Extinction, Psychological / physiology*
Globus Pallidus / physiology*
Male
Obsessive-Compulsive Disorder / physiopathology
Obsessive-Compulsive Disorder / therapy
Rats
Rats, Sprague-Dawley