[Natriuretic peptides as cardiac markers in clinical practice]

Ugeskr Laeger. 2010 Jul 26;172(30):2111-6.
[Article in Danish]

Abstract

Cardiac natriuretic peptides, BNP and NT-proBNP can be used to screen for left ventricular systolic dysfunction in patients with symptoms suggestive of heart failure. Using the cut-off values recommended in the article, the sensitivity and negative predictive values are high in patients aged < 75 years, but have lower sensitivity at older age. In addition, natriuretic peptides are prognostic markers for mortality and cardiovascular hospitalization. BNP/NT-proBNP measurement may also be of value in follow-up on heart failure patients.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Age Factors
  • Aged
  • Biomarkers / blood*
  • Heart Failure / blood
  • Heart Failure / diagnosis*
  • Humans
  • Middle Aged
  • Natriuretic Peptide, Brain / blood*
  • Peptide Fragments / blood*
  • Predictive Value of Tests
  • Prognosis
  • Reference Values
  • Risk Factors
  • Sensitivity and Specificity
  • Ventricular Dysfunction, Left / blood
  • Ventricular Dysfunction, Left / diagnosis*

Substances

  • Biomarkers
  • Peptide Fragments
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain