Lethal outcome of 5-fluorouracil infusion in a patient with a total DPD deficiency and a double DPYD and UTG1A1 gene mutation

Br J Clin Pharmacol. 2010 Aug;70(2):280-3. doi: 10.1111/j.1365-2125.2010.03686.x.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adenocarcinoma / drug therapy
  • Adenocarcinoma / genetics*
  • Aged
  • Antimetabolites, Antineoplastic / adverse effects*
  • Colonic Neoplasms / drug therapy*
  • Colonic Neoplasms / surgery
  • Dihydropyrimidine Dehydrogenase Deficiency*
  • Dihydrouracil Dehydrogenase (NADP) / genetics*
  • Fatal Outcome
  • Fluorouracil / adverse effects*
  • Fluorouracil / metabolism
  • Humans
  • Infusion Pumps
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / secondary*
  • Liver Neoplasms / surgery
  • Male
  • Mutation
  • Phenotype
  • Uracil / analogs & derivatives
  • Uracil / blood

Substances

  • Antimetabolites, Antineoplastic
  • dihydrouracil
  • Uracil
  • Dihydrouracil Dehydrogenase (NADP)
  • Fluorouracil