New multicomponent approach for the synthesis of benzo[c]coumarin derivatives over MgO under solvent-free conditions

Mol Divers. 2011 Feb;15(1):233-7. doi: 10.1007/s11030-010-9260-7. Epub 2010 Jul 22.

Abstract

In this study, a three-component one-pot synthesis of select 5-amino-6-cyano-3-hydroxybenzo[c]coumarin compounds derived from salicylaldehydes, malononitrile, and ethyl acetoacetate is reported. The reaction is conducted on grinding over MgO at room temperature resulting in good yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetoacetates / chemistry
  • Aldehydes / chemistry
  • Coumarins / chemical synthesis*
  • Coumarins / chemistry*
  • Magnesium Oxide / chemistry*
  • Nitriles / chemistry
  • Solvents / chemistry
  • Temperature

Substances

  • Acetoacetates
  • Aldehydes
  • Coumarins
  • Nitriles
  • Solvents
  • salicylaldehyde
  • Magnesium Oxide
  • dicyanmethane
  • ethyl acetoacetate