Abstract
The case of an adolescent female patient with acute lymphoblastic leukemia and stroke-like hemiparesis demonstrates a typical manifestation of methotrexate-induced acute encephalopathy. This rare entity occurs both in children and adults and can result from intrathecal as well as high dose intravenous administration of methotrexate. Diagnosis can confidently be made using cerebral MRI including diffusion-weighted imaging (DWI), so that patients can be informed about the favorable prognosis.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adolescent
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Antimetabolites, Antineoplastic / administration & dosage
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Antimetabolites, Antineoplastic / adverse effects*
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Brain / drug effects
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Brain / pathology
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Cytarabine / administration & dosage
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Diffusion Magnetic Resonance Imaging
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Dose-Response Relationship, Drug
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Female
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Humans
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Infusions, Intravenous
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Injections, Spinal
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Methotrexate / administration & dosage
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Methotrexate / adverse effects*
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Neurologic Examination / drug effects
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Neurotoxicity Syndromes / diagnosis*
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Paresis / chemically induced*
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Paresis / diagnosis
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Substances
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Antimetabolites, Antineoplastic
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Cytarabine
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Methotrexate