In vitro effect of acrylonitrile on specific activities of human polymorphonuclear leucocytes

M Governa; M Valentino; F Monaco; I Visoná; M Amati

doi:10.1016/0887-2333(95)00089-5

In vitro effect of acrylonitrile on specific activities of human polymorphonuclear leucocytes

Toxicol In Vitro. 1995 Dec;9(6):945-50. doi: 10.1016/0887-2333(95)00089-5.

Authors

M Governa¹, M Valentino, F Monaco, I Visoná, M Amati

Affiliation

¹ Clinica di Medicina del Lavoro Università di Ancona, Ospedale di Torrette, 60020 Torrette di Ancona, Italy.

PMID: 20650172
DOI: 10.1016/0887-2333(95)00089-5

Abstract

N-Formyl-methionyl-leucyl-phenylalanine (F-MLP)-induced chemotaxis and luminolamplified chemiluminescence were studied in isolated human polymorphonuclear leucocytes (PMN) and exposed to acrylonitrile (ACN) in vitro. Chemotaxis was reduced at ACN concentrations of 3 mm and above, while respiratory burst was affected at ACN concentrations of 18mm and above. The ACN concentrations were highly correlated both with decreased chemotactic activity (r = 0.75; P < 0.05) and with decreased respiratory burst (r = 0.93; P < 0.01).