Abstract
Exsanguinating hemorrhage and unavailability of blood are major problems in pre-hospital trauma care. We investigated if combining rFVIIa with HBOC-201 reduces blood loss and improves physiologic parameters compared to HBOC alone. Swine underwent liver injury and were resuscitated with HBOC-201 alone or HBOC+90, 180 or 360 μg/kg rFVIIa before hospital arrival at 240 min; animals survived to 72 hours. Blood loss was reduced; MAP, CI, transcutaneous oxygen saturation, and 72-hour survival improved in the 90 and 180 μg/kg rFVIIa groups. Lactate was cleared faster in the HBOC+rFVIIa 90 μg/kg group. Verification in a large, well-powered study is indicated.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Blood Gas Analysis / methods
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Blood Pressure / physiology
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Blood Substitutes / administration & dosage*
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Factor VIIa / administration & dosage*
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Female
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Fluid Therapy / methods*
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Heart Rate / physiology
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Hemoglobins / administration & dosage*
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Hemorrhage / mortality
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Hemorrhage / therapy*
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Lactic Acid / analysis
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Lactic Acid / blood
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Liver / injuries
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Male
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Recombinant Proteins / administration & dosage
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Resuscitation
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Survival Rate
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Swine
Substances
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Blood Substitutes
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Hemoglobins
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Recombinant Proteins
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HBOC 201
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Lactic Acid
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recombinant FVIIa
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Factor VIIa