Abstract
Induction of terminal erythroid differentiation can be an efficient strategy to inhibit proliferation of chronic myelogenous leukemia cells. Psoralens, well-known photo-chemotherapeutic agents, were found to be efficient at inducing erythroid differentiation of K562 cells, an in vitro cell line isolated from the pleural effusion of a patient with chronic myelogenous leukemia in blast crisis. The effects of crude pre-irradiated solutions of 5-methoxypsoralen on erythroid differentiation of human leukemic K-562 cells were evaluated. The major photoproduct was characterized and analyzed, and it was found to induce erythroid differentiation of K562 cells and inhibit NF-kappaB/DNA interactions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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5-Methoxypsoralen
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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Cell Differentiation
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Erythroid Cells / cytology*
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Erythroid Cells / drug effects
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Heterocyclic Compounds, 4 or More Rings / chemistry*
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Heterocyclic Compounds, 4 or More Rings / therapeutic use
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Humans
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Isomerism
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K562 Cells
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism
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Methoxsalen / analogs & derivatives*
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Methoxsalen / chemistry
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Methoxsalen / radiation effects
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Molecular Conformation
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NF-kappa B / metabolism
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Photolysis
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Ultraviolet Rays*
Substances
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Antineoplastic Agents
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Heterocyclic Compounds, 4 or More Rings
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NF-kappa B
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5-Methoxypsoralen
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Methoxsalen