Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities

ChemMedChem. 2010 Sep 3;5(9):1444-9. doi: 10.1002/cmdc.201000198.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemical synthesis
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / therapeutic use
  • Arachidonate 5-Lipoxygenase / chemistry*
  • Arachidonate 5-Lipoxygenase / metabolism
  • Drug Design
  • Edema / chemically induced
  • Edema / drug therapy
  • Hydroxyurea / analogs & derivatives*
  • Hydroxyurea / chemical synthesis
  • Hydroxyurea / chemistry
  • Hydroxyurea / therapeutic use
  • Leukotriene B4 / metabolism
  • Lipoxygenase Inhibitors / chemical synthesis
  • Lipoxygenase Inhibitors / chemistry*
  • Lipoxygenase Inhibitors / therapeutic use
  • Nitric Oxide / metabolism*
  • Rats
  • Structure-Activity Relationship

Substances

  • Anti-Inflammatory Agents
  • Lipoxygenase Inhibitors
  • Leukotriene B4
  • Nitric Oxide
  • Arachidonate 5-Lipoxygenase
  • zileuton
  • Hydroxyurea