Abstract
N-Methylpiperazinyl amides of betulinic, platanic, glycyrrhetic, oleanolic, ursolic, and moronic acids were synthesized and modified. Betulin and betulonic acid showed antimicrobial activity against Staphylococcus aureus at a concentration of 90 mg/ml, and betulin manifested a bacteriostatic effect against Klebsiella pneumoniae at a concentration of 60 mg/ml. Among the studied N-methylpiperazinyl amides, the highest activity against S. aureus was observed for a betulonic acid derivative.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis*
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Amides / chemistry
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Amides / pharmacology
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Colony Count, Microbial
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Klebsiella pneumoniae / drug effects
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Piperazines / chemical synthesis*
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Piperazines / chemistry
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Piperazines / pharmacology
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Staphylococcus aureus / drug effects
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Structure-Activity Relationship
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Triterpenes / chemical synthesis*
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Triterpenes / chemistry
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Triterpenes / pharmacology
Substances
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Amides
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Anti-Bacterial Agents
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Piperazines
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Triterpenes