Imaging-genetics applications in child psychiatry

J Am Acad Child Adolesc Psychiatry. 2010 Aug;49(8):772-82. doi: 10.1016/j.jaac.2009.12.022. Epub 2010 Apr 9.

Abstract

Objective: To place imaging-genetics research in the context of child psychiatry.

Method: A conceptual overview is provided, followed by discussion of specific research examples.

Results: Imaging-genetics research is described linking brain function to two specific genes, for the serotonin-reuptake-transporter protein and a monoamine oxidase enzyme. Work is then described on phenotype selection in imaging genetics.

Conclusions: Child psychiatry applications of imaging genetics are only beginning to emerge. The approach holds promise for advancing understandings of pathophysiology and therapeutics.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Animals
  • Brain / physiopathology
  • Child
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Magnetic Resonance Imaging*
  • Magnetic Resonance Spectroscopy*
  • Mental Disorders / diagnosis*
  • Mental Disorders / genetics*
  • Mental Disorders / physiopathology
  • Monoamine Oxidase / genetics
  • Phenotype
  • Polymorphism, Genetic / genetics
  • Serotonin Plasma Membrane Transport Proteins / genetics

Substances

  • Serotonin Plasma Membrane Transport Proteins
  • Monoamine Oxidase