Successful treatment of vancomycin-resistant Enterococcus faecium ventriculitis with combined intravenous and intraventricular chloramphenicol in a newborn

Carolin Hartmann; Corinna Peter; Elvis Hermann; Benno Ure; Ludwig Sedlacek; Gesine Hansen; Bettina Bohnhorst

doi:10.1099/jmm.0.022921-0

Successful treatment of vancomycin-resistant Enterococcus faecium ventriculitis with combined intravenous and intraventricular chloramphenicol in a newborn

J Med Microbiol. 2010 Nov;59(Pt 11):1371-1374. doi: 10.1099/jmm.0.022921-0. Epub 2010 Jul 15.

Authors

Carolin Hartmann¹, Corinna Peter¹, Elvis Hermann², Benno Ure³, Ludwig Sedlacek⁴, Gesine Hansen¹, Bettina Bohnhorst¹

Affiliations

¹ Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
² Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
³ Department of Pediatric Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
⁴ Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

PMID: 20634329
DOI: 10.1099/jmm.0.022921-0

Abstract

Vancomycin-resistant Enterococcus faecium (VRE) infection is a rare event in paediatric patients and often occurs under immunosuppression or after surgical intervention. We report what we believe to be the first paediatric case of ventriculitis due to VRE (in a 2-month-old infant) to be successfully treated with combined intravenous (i.v.) and intraventricular chloramphenicol after failure of i.v. linezolid and intraventricular gentamicin.

Publication types

Case Reports

MeSH terms

Acetamides / administration & dosage
Anti-Bacterial Agents / administration & dosage*
Cerebral Ventricles / microbiology*
Cerebral Ventricles / pathology
Cerebrospinal Fluid / cytology
Cerebrospinal Fluid / microbiology
Chloramphenicol / administration & dosage*
Encephalitis / diagnosis*
Encephalitis / drug therapy
Enterococcus faecium / drug effects
Enterococcus faecium / isolation & purification*
Female
Gentamicins / administration & dosage
Gram-Positive Bacterial Infections / diagnosis*
Gram-Positive Bacterial Infections / drug therapy
Head / diagnostic imaging
Humans
Infant, Newborn
Infusions, Intravenous
Injections, Intraventricular
Linezolid
Lumbosacral Region / diagnostic imaging
Magnetic Resonance Imaging
Oxazolidinones / administration & dosage
Pelvis / diagnostic imaging
Radiography
Treatment Outcome
Vancomycin Resistance*

Substances

Acetamides
Anti-Bacterial Agents
Gentamicins
Oxazolidinones
Chloramphenicol
Linezolid