Inhibitors of osteoclastogenesis from Lawsonia inermis leaves

Bioorg Med Chem Lett. 2010 Aug 15;20(16):4782-4. doi: 10.1016/j.bmcl.2010.06.118. Epub 2010 Jun 25.

Abstract

Ten phenolic compounds (1-10) were isolated from a methanol extract of Lawsonia inermis leaves including two new ones, lawsoniasides A (1) and B (2). Their structures were elucidated by spectroscopic methods (NMR and FTICRMS) in combination with acid hydrolysis and GC analyses. Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-kappaB ligand-induced osteoclast formation in murine bone-marrow macrophages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Glucosides / chemistry*
  • Glucosides / isolation & purification
  • Glucosides / pharmacology
  • Lawsonia Plant / chemistry*
  • Macrophages / cytology
  • Macrophages / immunology
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Conformation
  • NF-kappa B / metabolism
  • Osteoclasts / drug effects*
  • Phenylpropionates / chemistry*
  • Phenylpropionates / isolation & purification
  • Phenylpropionates / pharmacology
  • Phloroglucinol / analogs & derivatives*
  • Phloroglucinol / chemistry
  • Phloroglucinol / isolation & purification
  • Phloroglucinol / pharmacology
  • Plant Leaves / chemistry

Substances

  • Glucosides
  • NF-kappa B
  • Phenylpropionates
  • lawsoniaside A
  • lawsoniaside B
  • Phloroglucinol