This is a description of two cases of subcutaneous fat necrosis due to asphyxia in two newborns, and associated hypercalcaemia. Treatment with intravenous pamidronate 0.5 mg/kg for three days was very successful and well-tolerated. In conclusion, the treatment of hypercalcaemia was effective, but requires continuous control for a longer period of time due to the risk of fluctuating serum calcium levels.