"Lantern-Shaped" Platinum(III) Complexes with Axially Bound 9-Ethylguanine or 1-Methylcytosine (L) of General Formula [Pt(2){HN=C(Bu)O}(4)L(2)](NO(3))(2)

Concetta Pacifico; Francesco Paolo Intini; Fiorentin Nushi; Giovanni Natile

doi:10.1155/2010/102863

"Lantern-Shaped" Platinum(III) Complexes with Axially Bound 9-Ethylguanine or 1-Methylcytosine (L) of General Formula [Pt(2){HN=C(Bu)O}(4)L(2)](NO(3))(2)

Bioinorg Chem Appl. 2010:2010:102863. doi: 10.1155/2010/102863. Epub 2010 Jun 8.

Authors

Concetta Pacifico¹, Francesco Paolo Intini, Fiorentin Nushi, Giovanni Natile

Affiliation

¹ Dipartimento Farmaco-Chimico, Università degli Studi di Bari, Via E. Orabona 4, 70125 Bari, Italy.

Abstract

The synthesis, NMR characterization, and X-ray crystallography of "lantern-shaped" platinum(III) complexes with four pivaloamidate bridging ligands and two 9-ethylguanines (9-EtG) or 1-methylcytosines (1-MeC) in axial positions are reported: cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(9-EtG)(2)](NO(3))(2) and cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(1-MeC)(2)](NO(3))(2). The last complex is, to the best of our knowledge, the first dinuclear compound of platinum(III) with axially bound 1-MeC.