Syntheses of novel azasugar-containing mimics of heparan sulfate fragments as potential heparanase inhibitors

Kirsty A Allen; Rosemary L Brown; Gillian Norris; Peter C Tyler; Derek K Watt; Olga V Zubkova

doi:10.1016/j.carres.2010.05.032

Syntheses of novel azasugar-containing mimics of heparan sulfate fragments as potential heparanase inhibitors

Carbohydr Res. 2010 Sep 3;345(13):1831-41. doi: 10.1016/j.carres.2010.05.032. Epub 2010 Jun 4.

Authors

Kirsty A Allen¹, Rosemary L Brown, Gillian Norris, Peter C Tyler, Derek K Watt, Olga V Zubkova

Affiliation

¹ Carbohydrate Chemistry, Industrial Research Limited, Lower Hutt, New Zealand.

PMID: 20630499
DOI: 10.1016/j.carres.2010.05.032

Abstract

A series of eight novel, highly modified mono-, di- and trisaccharide derivatives, each containing an iminoalditol moiety, has been synthesized in the quest for potential heparanase inhibitors.

MeSH terms

Aza Compounds / chemistry*
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Glucuronidase / antagonists & inhibitors*
Heparitin Sulfate / analogs & derivatives
Heparitin Sulfate / chemical synthesis*
Heparitin Sulfate / chemistry
Heparitin Sulfate / pharmacology*
Humans

Substances

Aza Compounds
Enzyme Inhibitors
Heparitin Sulfate
heparanase
Glucuronidase