Abstract
A new carbazole alkaloid, sansoakamine (8), together with 11 known compounds, was isolated from the stems of Clausena excavata. All structures were elucidated by spectroscopic methods. Compound 7 showed moderate anti-malarial activity against Plasmodium falciparum with a MIC value of 6.74 microg/ml.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology*
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Carbazoles / chemistry
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Carbazoles / isolation & purification*
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Carbazoles / pharmacology*
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Clausena / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Parasitic Sensitivity Tests
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Plant Stems / chemistry
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Plants, Medicinal / chemistry*
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Plasmodium falciparum / drug effects*
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Thailand
Substances
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Alkaloids
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Antimalarials
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Carbazoles
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sansoakamine