Carbazole alkaloids from the stems of Clausena excavata

J Asian Nat Prod Res. 2010 Jul;12(7):614-7. doi: 10.1080/10286020.2010.482524.

Abstract

A new carbazole alkaloid, sansoakamine (8), together with 11 known compounds, was isolated from the stems of Clausena excavata. All structures were elucidated by spectroscopic methods. Compound 7 showed moderate anti-malarial activity against Plasmodium falciparum with a MIC value of 6.74 microg/ml.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Antimalarials / chemistry
  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology*
  • Carbazoles / chemistry
  • Carbazoles / isolation & purification*
  • Carbazoles / pharmacology*
  • Clausena / chemistry*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Parasitic Sensitivity Tests
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry*
  • Plasmodium falciparum / drug effects*
  • Thailand

Substances

  • Alkaloids
  • Antimalarials
  • Carbazoles
  • sansoakamine