Lack of association between cerebral microbleeds and low serum cholesterol in patients with acute intracerebral hemorrhage

Clin Neurol Neurosurg. 2010 Oct;112(8):668-71. doi: 10.1016/j.clineuro.2010.05.004. Epub 2010 Jun 2.

Abstract

Background: The association of cerebral microbleeds (CMBs) with intracerebral hemorrhage (ICH) is well known and its relationship with low serum cholesterol in ICH patients might be of interest.

Methods: A total of 105 patients with ICH were evaluated. In all subjects cholesterol levels were measured after 12h of fasting and gradient-echo magnetic resonance imaging (GE-MRI) was performed for detecting CMBs.

Results: CMBs were more common among patients with hypertension and leukoaraiosis (p=0.008 and p=0.001). Patients with and without CMBs did not differ according to total cholesterol, LDL cholesterol, triglycerides and HDL cholesterol levels.

Conclusion: In this study, 61% of Turkish ICH patients had CMBs, which was not associated with lipid profiles. Leukoaraiosis was independently associated with CMBs.

MeSH terms

  • Aged
  • Brain / blood supply
  • Brain / pathology
  • Cholesterol / blood*
  • Female
  • Humans
  • Intracranial Hemorrhages / blood*
  • Intracranial Hemorrhages / complications
  • Intracranial Hemorrhages / pathology
  • Leukoaraiosis / complications*
  • Leukoaraiosis / pathology
  • Male
  • Microcirculation
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Turkey

Substances

  • Cholesterol