Abstract
The aim of the study was to evaluate the proliferative effects of chishao on neuron regeneration. A silicone rubber nerve guide across a 15-mm gap was filled with different concentrations of chishao (0-125 mg/ml) in the dissected sciatic nerve of the right leg in SD rats. The left legs were used as control. After eight weeks, the regenerated nerves showed dose-dependently activated fibroblast growth factor-2 (FGF-2) signaling with increased urokinase plasminogen activator (uPA), decreased plasminogen activator inhibitor-1 (PAI-1) and enhanced proliferative proteins, extracellular signal regulated kinase (ERK)- and c-Jun N-terminal kinase (JNK)-signalings. The results imply that applying an appropriate dose of chishao would be a potential approach for enhancing neuron regeneration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Proliferation / drug effects*
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Dose-Response Relationship, Drug
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Drugs, Chinese Herbal / pharmacology*
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Extracellular Signal-Regulated MAP Kinases / metabolism
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Fibroblast Growth Factor 2 / metabolism
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JNK Mitogen-Activated Protein Kinases / metabolism
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Nerve Regeneration / drug effects*
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Neurons / drug effects*
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Neurons / metabolism
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Paeonia*
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Phytotherapy
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Plant Roots
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Plasminogen Activator Inhibitor 1 / metabolism
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Rats
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Rats, Sprague-Dawley
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Sciatic Nerve / drug effects
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Sciatic Nerve / metabolism
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Signal Transduction / drug effects*
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Urokinase-Type Plasminogen Activator / metabolism
Substances
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Drugs, Chinese Herbal
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Plasminogen Activator Inhibitor 1
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Fibroblast Growth Factor 2
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Extracellular Signal-Regulated MAP Kinases
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JNK Mitogen-Activated Protein Kinases
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Urokinase-Type Plasminogen Activator