Abstract
Selaginellins G (1) and H (2), two new selaginellin derivatives, were isolated from the whole plant of Selaginella pulvinata. Their structures were elucidated, and complete assignments of the (1)H and (13)C NMR spectroscopic data were achieved by 1D and 2D NMR experiments (HSQC, HMBC, COSY and ROESY). Compound 1 displayed good antifungal activity against Candida albicans with an IC(50) value of 5.3 microg/ml.
2010 John Wiley & Sons, Ltd.
MeSH terms
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Antifungal Agents / chemistry*
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Candida albicans / drug effects
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Magnetic Resonance Spectroscopy / standards
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Microbial Sensitivity Tests
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Molecular Structure
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Reference Standards
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Selaginellaceae / chemistry*
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Trityl Compounds / chemistry*
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Trityl Compounds / isolation & purification
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Trityl Compounds / pharmacology
Substances
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Antifungal Agents
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Trityl Compounds
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selaginellin G