Structure determination of selaginellins G and H from Selaginella pulvinata by NMR spectroscopy

Magn Reson Chem. 2010 Aug;48(8):656-9. doi: 10.1002/mrc.2623.

Abstract

Selaginellins G (1) and H (2), two new selaginellin derivatives, were isolated from the whole plant of Selaginella pulvinata. Their structures were elucidated, and complete assignments of the (1)H and (13)C NMR spectroscopic data were achieved by 1D and 2D NMR experiments (HSQC, HMBC, COSY and ROESY). Compound 1 displayed good antifungal activity against Candida albicans with an IC(50) value of 5.3 microg/ml.

Publication types

  • Letter

MeSH terms

  • Antifungal Agents / chemistry*
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology
  • Candida albicans / drug effects
  • Magnetic Resonance Spectroscopy / standards
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Reference Standards
  • Selaginellaceae / chemistry*
  • Trityl Compounds / chemistry*
  • Trityl Compounds / isolation & purification
  • Trityl Compounds / pharmacology

Substances

  • Antifungal Agents
  • Trityl Compounds
  • selaginellin G