Abstract
Anti-Ku antibodies are reported in various connective tissue diseases and the Ku complex can be responsible for a very strong autoimmune answer in autoimmune disease. Nowadays, anti-Ku antibodies are detected by ELISA, counterimmunoelectrophoresis (CIE), immunoblot (IB) and new highly performant techniques. Although the prevalence of anti-Ku antibodies is not homogenous, depending on several features such as disease type, genetic and geographical clustering, and also method of detection, they could be found in 55% overlap PM/systemic sclerosis patients. Moreover, anti-Ku antibodies are not associated with a particular clinical outcome, and especially with cancer related to myositis.
2010 Elsevier B.V. All rights reserved.
MeSH terms
-
Antigens, Nuclear / genetics
-
Antigens, Nuclear / immunology*
-
Antigens, Nuclear / metabolism
-
Autoantibodies / immunology
-
Autoantibodies / metabolism*
-
Autoimmune Diseases / diagnosis
-
Autoimmune Diseases / epidemiology
-
Autoimmune Diseases / genetics
-
Autoimmune Diseases / immunology*
-
Connective Tissue Diseases / diagnosis
-
Connective Tissue Diseases / epidemiology
-
Connective Tissue Diseases / genetics
-
Connective Tissue Diseases / immunology*
-
DNA-Activated Protein Kinase / metabolism
-
DNA-Binding Proteins / genetics
-
DNA-Binding Proteins / immunology*
-
DNA-Binding Proteins / metabolism
-
Genetic Predisposition to Disease
-
Humans
-
Ku Autoantigen
-
Nuclear Proteins / metabolism
-
Prevalence
-
Racial Groups
-
Risk Factors
Substances
-
Antigens, Nuclear
-
Autoantibodies
-
DNA-Binding Proteins
-
Nuclear Proteins
-
DNA-Activated Protein Kinase
-
PRKDC protein, human
-
Xrcc6 protein, human
-
Ku Autoantigen