Structure-activity relationship in binding ligands to library of artificial receptors: the search for biocompatible sensor

Bioelectrochemistry. 2010 Nov;80(1):2-9. doi: 10.1016/j.bioelechem.2010.06.001. Epub 2010 Jun 12.

Abstract

Structure-activity relationship (SAR) analysis was applied for studies of docking of colored ligands to library of artificial receptors formed by self-assembly of N-lipidated amino acids immobilised on the cellulose support. The studies show that the binding depends mainly on the structure of amino acid fragment but influence of N-lipidic fragment is less important.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry
  • Amino Acids / metabolism
  • Binding Sites
  • Biocompatible Materials / chemistry*
  • Biocompatible Materials / metabolism
  • Biosensing Techniques / methods*
  • Cellulose / chemistry
  • Coloring Agents / chemistry
  • Coloring Agents / metabolism
  • Combinatorial Chemistry Techniques / methods*
  • Enzymes, Immobilized / chemistry
  • Enzymes, Immobilized / metabolism
  • Ligands
  • Lipids / chemistry
  • Nitrogen / chemistry
  • Nitrogen / metabolism
  • Proteins / chemistry*
  • Proteins / metabolism
  • Receptors, Peptide / chemistry*
  • Receptors, Peptide / metabolism
  • Structure-Activity Relationship
  • Triazines / chemistry
  • Triazines / metabolism

Substances

  • Amino Acids
  • Biocompatible Materials
  • Coloring Agents
  • Enzymes, Immobilized
  • Ligands
  • Lipids
  • Proteins
  • Receptors, Peptide
  • Triazines
  • Cellulose
  • Nitrogen