5-HTTLPR polymorphism influences prefrontal neurochemical metabolites in autism spectrum disorder

Taro Endo; Hideaki Kitamura; Ryu Tamura; Jun Egawa; Takuro Sugai; Naoki Fukui; Yutaro Suzuki; Toshiyuki Someya

doi:10.1016/j.pscychresns.2010.04.015

5-HTTLPR polymorphism influences prefrontal neurochemical metabolites in autism spectrum disorder

Psychiatry Res. 2010 Aug 30;183(2):170-3. doi: 10.1016/j.pscychresns.2010.04.015. Epub 2010 Jul 8.

Authors

Taro Endo¹, Hideaki Kitamura, Ryu Tamura, Jun Egawa, Takuro Sugai, Naoki Fukui, Yutaro Suzuki, Toshiyuki Someya

Affiliation

¹ Department of Psychiatry, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan. tarou@med.niigata-u.ac.jp

PMID: 20619617
DOI: 10.1016/j.pscychresns.2010.04.015

Abstract

We investigated whether the promoter region of the serotonin transporter gene (5-HTTLPR) polymorphism influenced neurochemical metabolism in 26 individuals with autism spectrum disorder. Individuals with the S/S genotype of the 5-HTTLPR polymorphism showed significantly lower levels of N-acetylaspartate/creatine in the right medial prefrontal cortex compared with those with the S/L genotype.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Analysis of Variance
Aspartic Acid / analogs & derivatives
Aspartic Acid / metabolism
Child
Child Development Disorders, Pervasive / genetics*
Child Development Disorders, Pervasive / pathology*
Creatine / metabolism
Female
Humans
Magnetic Resonance Spectroscopy / methods
Male
Neurochemistry*
Polymorphism, Genetic / genetics*
Prefrontal Cortex / metabolism*
Protons
Serotonin Plasma Membrane Transport Proteins / genetics*

Substances

Protons
SLC6A4 protein, human
Serotonin Plasma Membrane Transport Proteins
Aspartic Acid
N-acetylaspartate
Creatine