Improved arene fluorination methodology for I(III) salts

Bijia Wang; Linlin Qin; Kiel D Neumann; ShriHarsha Uppaluri; Ronald L Cerny; Stephen G DiMagno

doi:10.1021/ol101154h

Improved arene fluorination methodology for I(III) salts

Org Lett. 2010 Aug 6;12(15):3352-5. doi: 10.1021/ol101154h.

Authors

Bijia Wang¹, Linlin Qin, Kiel D Neumann, ShriHarsha Uppaluri, Ronald L Cerny, Stephen G DiMagno

Affiliation

¹ Department of Chemistry and Nebraska Center for Materials and Nanoscience, University of Nebraska, Lincoln, Nebraska 68588-0304, USA.

Abstract

The use of low polarity aromatic solvents (benzene or toluene) and/or the removal of inorganic salts results in dramatically improved yields of fluorinated arenes from diaryliodonium salts. This methodology is shown to "scale down" to the conditions used typically for radiotracer synthesis.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Benzene Derivatives / chemistry*
Halogenation*
Indicators and Reagents / chemistry
Molecular Structure
Salts / chemistry*

Substances

Benzene Derivatives
Indicators and Reagents
Salts

Abstract

Publication types

MeSH terms

Substances

Grants and funding