Abstract
A 45-year-old woman, complaining of back pain and bloody stool was given a diagnosis of poorly differentiated adenocarcinoma of the rectum with disseminated carcinomatosis to bone marrow and disseminated intravascular coagulation syndrome (DIC). We started chemotherapy using mFOLFOX-6 with simultaneous DIC treatment. After we confirmed that DIC had improved following 2 courses of mFOLFOX-6, bevacizumab was added to mFOLFOX-6. Laboratory studies revealed a serum CEA level of 314.4ng/ml, which improved to 4.6ng/ml after a total of 6 courses of chemotherapy. Colonoscopy findings showed almost normal rectal mucosa after a total of 10 courses of chemotherapy. Outpatient treatment was started after 5 courses of chemotherapy, and was continuing according to schedule at 7 months from the onset of this disease.
Publication types
-
Case Reports
-
English Abstract
-
Review
MeSH terms
-
Adenocarcinoma / complications
-
Adenocarcinoma / drug therapy*
-
Antibodies, Monoclonal / administration & dosage*
-
Antibodies, Monoclonal, Humanized
-
Antineoplastic Combined Chemotherapy Protocols / administration & dosage
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
-
Bevacizumab
-
Bone Marrow Neoplasms / drug therapy*
-
Bone Marrow Neoplasms / etiology
-
Carcinoma / drug therapy*
-
Carcinoma / etiology
-
Female
-
Fluorouracil / administration & dosage
-
Humans
-
Leucovorin / administration & dosage
-
Middle Aged
-
Organoplatinum Compounds / administration & dosage
-
Rectal Neoplasms / complications
-
Rectal Neoplasms / drug therapy*
Substances
-
Antibodies, Monoclonal
-
Antibodies, Monoclonal, Humanized
-
Organoplatinum Compounds
-
Bevacizumab
-
Leucovorin
-
Fluorouracil