Synthesis of functionalized chromenes from Meldrum's acid, 4-hydroxycoumarin, and ketones or aldehydes

Comb Chem High Throughput Screen. 2010 Nov;13(9):813-7. doi: 10.2174/138620710792927358.

Abstract

An efficient synthesis of 4-alkyl-4-methyl-3,4-dihydro-2H,5H-pyrano[3,2-c]chromene-2,5-dione or 4-aryl-3,4-dihydro-2H,5H-pyrano[3,2-c]chromene-2,5-diones via reaction 4-hydroxycoumarin with Meldrum's acid and ketones or aldehydes is described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Hydroxycoumarins / chemistry*
  • Aldehydes / chemistry*
  • Benzopyrans / chemical synthesis*
  • Dioxanes / chemistry*
  • Ketones / chemistry*
  • Molecular Structure

Substances

  • 4-Hydroxycoumarins
  • Aldehydes
  • Benzopyrans
  • Dioxanes
  • Ketones
  • Meldrum's acid
  • 4-hydroxycoumarin