This is a retrospective study with the aim to evaluate orbital floor reconstruction with autogenous bone and alloplastic materials consisting of Medpor, Medpor Titan, Titanium, and resorbable plates. We evaluated 101 patients with pure blow-out fracture or concomitant with zygomatic maxillary fracture. We reviewed patients' documentation before and after surgery and 12 months after reconstruction. Thirteen patients with Medpor, 42 patients with Medpor Titan, 30 patients with Titanium, 5 patients with calvarial bone graft, 8 patients with iliac bone graft, and 3 patients with bioresorbable plates were treated. Medpore and Medpor-Titan-Medpor 1.5 to 2 mm in thickness were used. Autogenous bone graft 3 to 5 mm in thickness was used. Results showed that autogenous and alloplastic materials could be used in orbital floor reconstruction; autogenous bone graft had minimal postoperative infection, and it is a good choice in major orbital defects. Titanium mesh and MTM with excellent structural support are used in large orbital floor defects. Resorbable plates are good alternative materials in pediatric patients.