Abstract
In this 13-week, open-label, randomized study of the anti-inflammatory salsalate versus usual care, there were no significant improvements in flow-mediated dilation of the brachial artery, endothelial activation, inflammation or coagulation markers, homeostasis model assessment of insulin resistance or lipoproteins with salsalate or between groups in virologically suppressed, HIV-infected adults on antiretrovirals. Tinnitus and transaminitis occurred frequently in the salsalate group. Dose reduction due to toxicities encountered and low level of inflammation may explain these results.
Publication types
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects
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Brachial Artery / physiopathology*
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Dose-Response Relationship, Drug
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Endothelium, Vascular / drug effects
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Endothelium, Vascular / physiopathology*
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Female
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HIV Infections / drug therapy
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HIV Infections / physiopathology*
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Humans
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Insulin Resistance
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Male
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Salicylates / administration & dosage*
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Salicylates / adverse effects
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Salicylates
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salicylsalicylic acid