Abstract
A series of novel spiropyrrolidines and spirothiapyrrolizidines were synthesized via a three-component 1,3-dipolar cycloaddition reaction of isatin or acenaphthenequinone, sarcosine or thiaproline and 4-hydroxy-6-methyl-3-((E)-3-phenylacryloyl)-2H-pyran-2-ones in refluxing ethanol. Advantages of this method include the availability of starting materials, mild reaction conditions, high yields, and the complete regioselectivity observed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Azo Compounds / chemistry*
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Combinatorial Chemistry Techniques
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Crystallography, X-Ray
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Cyclization
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Models, Molecular
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Molecular Structure
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Pyrrolidines / chemical synthesis*
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Pyrrolidines / chemistry
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry
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Stereoisomerism
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Thiazolidines / chemical synthesis*
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Thiazolidines / chemistry
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Thiosemicarbazones / chemistry*
Substances
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Azo Compounds
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Pyrrolidines
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Spiro Compounds
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Thiazolidines
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Thiosemicarbazones
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azomethine