Abstract
We describe a 62-year-old man infected with human immunodeficiency virus (HIV)-1 who developed primary effusion lymphoma (PEL). Pleural effusion contained atypical lymphoid cells with human herpesvirus (HHV)-8 latent nuclear antigen (LANA)(+). Radiological examination revealed pleural and pericardial effusion, but no evidence of tumor mass or lymph node enlargement. The patient was administered with highly active anti retroviral therapy (HAART) and THP-COP therapy, resulting in complete remission. The prevalence of HHV-8 infection among HIV positive individuals is higher than in the general population in Japan. Although PEL is extremely rare in Japan, the incidence might increase in the future.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Antiretroviral Therapy, Highly Active
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Cyclophosphamide / administration & dosage
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Doxorubicin / administration & dosage
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Doxorubicin / analogs & derivatives
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HIV Infections / complications*
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HIV Infections / drug therapy
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Herpesviridae Infections / complications*
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Herpesviridae Infections / drug therapy
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Herpesvirus 8, Human*
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Humans
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Japan
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Lymphoma, Primary Effusion / diagnosis*
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Lymphoma, Primary Effusion / drug therapy
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Lymphoma, Primary Effusion / virology*
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Male
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Middle Aged
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Prednisolone / administration & dosage
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Vincristine / administration & dosage
Substances
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisolone