Metabolic networks of longevity

Cell. 2010 Jul 9;142(1):9-14. doi: 10.1016/j.cell.2010.06.029.

Abstract

Molecular and cellular networks implicated in aging depend on a multitude of proteins that collectively mount adaptive and contingent metabolic responses to environmental challenges. Here, we discuss the intimate links between metabolic regulation and longevity and outline new approaches for analyzing and manipulating such links to promote human health span.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / genetics
  • Aging / metabolism*
  • Amino Acids, Essential / metabolism*
  • Animals
  • Humans
  • Longevity*
  • Metabolic Networks and Pathways*
  • Methionine / metabolism*

Substances

  • Amino Acids, Essential
  • Methionine