Design of a novel phase contrast x-ray imaging system for mammography

Phys Med Biol. 2010 Jul 21;55(14):4169-85. doi: 10.1088/0031-9155/55/14/014. Epub 2010 Jul 5.

Abstract

It is hoped that x-ray phase contrast imaging (XPCi) will provide a generational improvement in the effectiveness of mammography. XPCi is sensitive to the refraction which x-rays undergo as a result of the variation in x-ray propagation speeds within an object. XPCi is, however, seldom used in clinical applications owing mainly to a lack of suitable systems. The radiation physics group at UCL has previously designed and built an XPCi system sensitive to phase gradients in one dimension for application in security inspection. We present here the design methodology and final design of a prototype XPCi system sensitive to phase gradients in two directions for use in mammography. The technique makes efficient use of the flux available from a laboratory x-ray source, thus making it suitable for clinical use.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorption
  • Algorithms
  • Breast / physiology
  • Breast / physiopathology
  • Breast / radiation effects
  • Breast Neoplasms / diagnostic imaging
  • Breast Neoplasms / physiopathology
  • Calcinosis / diagnostic imaging
  • Calcinosis / physiopathology
  • Computer Simulation
  • Equipment Design
  • Female
  • Humans
  • Lipids
  • Mammography / instrumentation*
  • Models, Biological
  • Photons
  • Water
  • X-Rays

Substances

  • Lipids
  • Water