Four new phenanthrenes from Monomeria barbata Lindl

Minghui Yang; Le Cai; Zhigang Tai; Xianghui Zeng; Zhongtao Ding

doi:10.1016/j.fitote.2010.06.019

Four new phenanthrenes from Monomeria barbata Lindl

Fitoterapia. 2010 Dec;81(8):992-7. doi: 10.1016/j.fitote.2010.06.019. Epub 2010 Jun 28.

Authors

Minghui Yang¹, Le Cai, Zhigang Tai, Xianghui Zeng, Zhongtao Ding

Affiliation

¹ Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.

PMID: 20600684
DOI: 10.1016/j.fitote.2010.06.019

Abstract

Three biphenanthrene compounds (1-3) and a triphenanthrene compound (4), together with six known biphenanthrene compounds (5-10), were isolated from the tubers of Monomeria barbata Lindl. Their structures were elucidated on the basis of extensive spectroscopic analysis (1D-, 2D-NMR, and HR-ESI-MS). These four new compounds were tested in vitro for the cytotoxic activity against liver carcinoma (HepG-2), promyelocytic leukaemia (HL60), ovarian carcinoma (Skov-3) and epidermoid carcinoma (A431) cancer cell lines and the antioxidant activity in DPPH radical scavenging. Compounds 1-4 exhibited significant cytotoxic activity against HepG-2 and HL60 cell lines, and potent antioxidant activity in DPPH radical scavenging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Molecular Structure
Orchidaceae / chemistry*
Phenanthrenes / chemistry*

Substances

Phenanthrenes