MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems

Genes Dev. 2010 Jul 1;24(13):1339-44. doi: 10.1101/gad.1937010.

Abstract

Biological systems are continuously challenged by an environment that is variable. Yet, a key feature of developmental and physiological processes is their remarkable stability. This review considers how microRNAs contribute to gene regulatory networks that confer robustness.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Epithelial Cells / cytology
  • Feedback, Physiological
  • Gene Regulatory Networks / genetics*
  • Genes, Switch / genetics
  • Humans
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism*
  • Neurons / cytology
  • Protein Interaction Domains and Motifs / physiology

Substances

  • MicroRNAs