Novel, one-pot, three-component route to indol-3-yl substituted spirooxindole derivatives

Tao Chen; Xiao-Ping Xu; Shun-Jun Ji

doi:10.1021/cc100064c

Novel, one-pot, three-component route to indol-3-yl substituted spirooxindole derivatives

J Comb Chem. 2010 Sep 13;12(5):659-63. doi: 10.1021/cc100064c.

Authors

Tao Chen¹, Xiao-Ping Xu, Shun-Jun Ji

Affiliation

¹ Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.

PMID: 20593846
DOI: 10.1021/cc100064c

Abstract

A simple and efficient approach to the synthesis of a novel series of polysubstituted 6'-(1H-indol-3-yl)-1',7'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-b]pyridine]-2-one derivatives in high yields was developed from a one-pot, three-component reaction of 3-cyanoacetyl indoles, isatins, and 1H-pyrazol-5-amines in H(2)O/HOAc.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Combinatorial Chemistry Techniques*
Indoles / chemical synthesis*
Indoles / chemistry*
Isatin / analogs & derivatives
Isatin / chemistry*
Molecular Structure
Pyrazoles / chemistry*
Spiro Compounds / chemical synthesis*
Spiro Compounds / chemistry
Stereoisomerism

Substances

1H-pyrazol-5-amine
Indoles
Pyrazoles
Spiro Compounds
Isatin