Novel one-pot method for chemoselective bromination and sequential Sonogashira coupling

Noriki Kutsumura; Kentaro Niwa; Takao Saito

doi:10.1021/ol101110v

Novel one-pot method for chemoselective bromination and sequential Sonogashira coupling

Org Lett. 2010 Aug 6;12(15):3316-9. doi: 10.1021/ol101110v.

Authors

Noriki Kutsumura¹, Kentaro Niwa, Takao Saito

Affiliation

¹ Department of Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. nkutsu@rs.kagu.tus.ac.jp

PMID: 20593774
DOI: 10.1021/ol101110v

Abstract

An efficient one-pot method for bromination-elimination of allyl alcohol derivatives and sequential Sonogashira coupling has been developed. A highlight of the method is chemoselective DBU-promoted elimination of vicinal dibromoalkanes having an adjacent O-functional group.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Combinatorial Chemistry Techniques
Halogenation*
Molecular Structure
Propanols / chemistry*

Substances

Propanols
allyl alcohol